This paper examines the use of Fluid-based Aerodynamic Modification (FAM) methods derived from flow control techniques first developed for the aerospace industry. Instead of relying on the adjustment of the solid material within the structure to improve the aerodynamics of a tall building, fluid-based active flow control is added to the building systems' matrix to manipulate the building boundary layer and achieve a desired performance for both the interior and exterior. Experimental results are presented to demonstrate proof of concept for the FAM approach to tall building aerodynamic modification.